Abstract #2587
The Variation of MAP-MRI derived Parameters along White Matter Fiber Pathways in the Human Brain
Alexandru V Avram 1 , Alan S Barnett 1,2 , and Peter J Basser 1
1
Section on Tissue Biophysics and Biomimetics,
NICHD, National Institutes of Health, Bethesda, MD,
United States,
2
The
Henry Jackson Foundation, Bethesda, MD, United States
Scalar indices derived from diffusion weighted MR images
(DWIs) provide invaluable clinical information for
characterizing changes in brain microstructure and
cytoarchitecture. In this study we apply the recently
developed mean apparent propagator (MAP)-MRI framework
to quantify the brain diffusion properties in healthy
volunteers and describe and interpret the variation of
scalar descriptors of the MAP (such as zero-displacement
probability, non-gaussianity and propagator anisotropy)
along the major white matter fiber pathways and discuss
the clinical significance of our findings.
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