Validation of a tract-based automatic analysis by comparison with manual tractography

In this study, we proposed a whole brain tract-specific analysis using a high quality DSI template, predetermined tracts in the template, and LDDMM coregistration method. Compared to manual approach, TBAA showed higher overlap of tract positions and smaller variability of the sampled GFA. In conclusion, TBAA overcomes the problem of variability in manual tractography on individual DSI, and is potentially useful in high-throughput tract-specific analysis of the whole brain.

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