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Abstract #2605

Characterizing Human Brain Microstructure with Mean Apparent Propagator (MAP) MRI

Alexandru V Avram 1 , Alan S Barnett 1,2 , Evren Ozarslan 1,3 , Joelle E Sarlls 4 , M. Okan Irfanoglu 1,2 , Elizabeth Hutchinson 1,5 , Carlo Pierpaoli 1 , and Peter J Basser 1

1 Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, Bethesda, MD, United States, 2 The Henry Jackson Foundation, Bethesda, MD, United States, 3 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 4 NINDS, National Institutes of Health, Bethesda, MD, United States, 5 Center for Neuroscience and Regenerative Medicine, USUHS, Bethesda, MD, United States

Orientationally invariant measures such as Fractional Anisotropy or mean diffusivity are invaluable for characterizing changes in cytoarchitecture and microanatomical organization of brain tissue during stroke, cancer, neurodegenerative diseases and aging. In this study we apply the recently developed MAP-MRI framework to measure displacement profiles of water molecules in healthy human volunteers. Moreover, we characterize the mean apparent diffusion propagator with novel orientationally invariant scalar measures of zero-displacement probability, non-gaussianity, and propagator anisotropy and evaluate the feasibility of generating such images from clinical acquisitions.

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