Abstract #2605
Characterizing Human Brain Microstructure with Mean Apparent Propagator (MAP) MRI
Alexandru V Avram 1 , Alan S Barnett 1,2 , Evren Ozarslan 1,3 , Joelle E Sarlls 4 , M. Okan Irfanoglu 1,2 , Elizabeth Hutchinson 1,5 , Carlo Pierpaoli 1 , and Peter J Basser 1
1
Section on Tissue Biophysics and Biomimetics,
NICHD, National Institutes of Health, Bethesda, MD,
United States,
2
The
Henry Jackson Foundation, Bethesda, MD, United States,
3
Department
of Radiology, Brigham and Women's Hospital, Harvard
Medical School, Boston, MA, United States,
4
NINDS,
National Institutes of Health, Bethesda, MD, United
States,
5
Center
for Neuroscience and Regenerative Medicine, USUHS,
Bethesda, MD, United States
Orientationally invariant measures such as Fractional
Anisotropy or mean diffusivity are invaluable for
characterizing changes in cytoarchitecture and
microanatomical organization of brain tissue during
stroke, cancer, neurodegenerative diseases and aging. In
this study we apply the recently developed MAP-MRI
framework to measure displacement profiles of water
molecules in healthy human volunteers. Moreover, we
characterize the mean apparent diffusion propagator with
novel orientationally invariant scalar measures of
zero-displacement probability, non-gaussianity, and
propagator anisotropy and evaluate the feasibility of
generating such images from clinical acquisitions.
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