Abstract #2633
Oscillating Gradient Diffusion MRI in the ex-vivo prostate to assess ADC behavior at small diffusion times
Andre Bongers 1 , Aritrick Chatterjee 2 , Geoffrey Watson 3 , and Roger Bourne 4
1
Mark Wainwright Analytical Centre,
University of New South Wales, Sydney, NSW, Australia,
2
University
of Sydney, Sydeny, NSW, Australia,
3
Royal
Prince Alfred Hospital, Sydney, NSW, Australia,
4
University
of Sydney, Sydney, NSW, Australia
As DWI is able to sensitively sample cellular changes in
tissues the method is a promising biomarker for prostate
cancer detection. Standard PGSE methods usually sample
ADCs in the long diffusion time regime, meaning that ADC
quantification is affected by cellular restrictions from
multiple scales. This study explores the ability of
oscillating gradient DWI (OGSE) methods to detect
subcellular changes in fixed and unfixed ex-vivo
prostate tissue at high magnetic field. Our findings
show that -in the short diffusion time regime-
ADC-diffusion-time behavior depends significantly on
prostate tissue type and suggest that that prostate
cancer induces intracellular structure changes.
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