Abstract #2638
Reproducibility and Normal Values of Microscopic Diffusion Anisotropy Measures and Their Variation in Healthy Volunteers
Marco Lawrenz 1,2 and Juergen Finsterbusch 1,2
1
Department of Systems Neuroscience,
University Medical Center Hamburg-Eppendorf, Hamburg,
Hamburg, Germany,
2
Neuroimage
Nord, University Medical Centers Hamburg-Kiel-Luebeck,
Hamburg-Kiel-Luebeck, Hamburg-Kiel-Luebeck, Germany
Double-wave-vector diffusion-weighting (DWV) experiments
with two weighting periods applied successively offer
access to microscopic tissue properties, e.g. the
diffusion anisotropy present on a microscopic scale.
This anisotropy is independent of the axon orientation
distribution and, thus, may better reflect axon
integrity than measures derived from DTI. To investigate
whether measures of th microscopic diffusion anisotropy,
e.g. the so-called MA index, are feasible for
application in clinical or neuroscientific research,
normal values in white matter and their variation within
a group of healthy volunteers as well as their
reproducability within and between sessions are
determined.
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