Preliminary Results on Measuring Intravoxel Incoherent Motion Using Oscillating Diffusion Gradients

Diffusion experiments using oscillating gradients are performed. In the pancreas of healthy volunteers, sine gradients were found to cause larger signal attenuation than cosine gradients of the same b-value. In addition, the signal attenuation was found to decrease for the cosine profile when the number of oscillations was increased. The experimental findings can be understood in the picture of temporal diffusion spectroscopy and in the intravoxel incoherent motion model. The method might be of particular interest for probing the microvasculature in organs in which the characteristic timescale of the incoherent motion is shorter than the echo time.

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