Abstract #2675
Analysis of Normal Appearing White Matter of Multiple Sclerosis by Tensor-based Two-Compartment Model of Water Diffusion
Yasuhiko Tachibana 1,2 , Takayuki Obata 2 , Mariko Yoshida 1 , Masaaki Hori 1 , Michimasa Suzuki 1 , Koji Kamagata 1 , Issei Fukunaga 1 , Kouhei Kamiya 1 , Kazumasa Yokoyama 3 , Nobutaka Hattori 3 , Tomio Inoue 4 , and Shigeki Aoki 1
1
Department of Radiology, Juntendo University
School of Medicine, Tokyo, Tokyo, Japan,
2
National
Institute of Radiological Science, Chiba, Chiba, Japan,
3
Department
of Neurology, Juntendo University School of Medicine,
Tokyo, Japan,
4
Yokohama
City University Graduate School of Medicine, Kanagawa,
Japan
Alterations in water diffusion are found in normal
appearing white matter (NAWM) of multiple sclerosis (MS)
patients. To detect more minor changes in this
condition, a new simple method was designed to assess
water diffusion using the two-compartment model combined
with diffusion tensor imaging. The method allowed
greater detectability of minimal changes in NAWM of MS
(apparent diffusion coefficient of slow diffusion
directed perpendicular to the fibers was higher with
significance in MS) compared to conventional
mono-exponential fit ADC.
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