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Abstract #2688

Investigating longitudinal changes in fractional anisotropy in Alzheimers disease using different registration methods

Sila Genc 1 , Christopher Steward 1,2 , Terence O'Brien 3,4 , and Patricia Desmond 1,2

1 Department of Radiology, University of Melbourne, Parkville, Victoria, Australia, 2 Department of Radiology, Royal Melbourne Hospital, Parkville, Victoria, Australia, 3 Department of Medicine, University of Melbourne, Parkville, Victoria, Australia, 4 Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia

Longitudinal changes in fractional anisotropy in Alzheimers disease patients were investigated using three different registration methods. Recent studies have suggested alterations to the TBSS pipeline in order to improve the registration process for subsequent image analysis. Replacing the standard registrations in the TBSS pipeline in FSL, with ANTs registrations, revealed minimal differences between the spatial distributions of FA change in the core white matter tracts within six months. The consistencies between the standard TBSS, ANTS-modified TBSS, and study-specific template results suggests that running the simple TBSS pipeline may be sufficient for longitudinal analyses in complex pathologies such as Alzheimers disease.

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