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Abstract #2697

Whole-brain distortion-free pseudo-continuous arterial spin labeling using multiband turbo-FLASH at 3 and 7T

Yi Wang 1 , Steen Moeller 2 , An T. Vu 2 , Kamil Ugurbil 2 , Essa Yacoub 2 , and Danny JJ Wang 1

1 Neurology, UCLA, Los Angeles, CA, United States, 2 Center of Magnetic Resonance Research, University of Minnesota, MN, United States

Multiband imaging or simultaneous multi-slice excitation has recently been applied for arterial spin labeling perfusion MRI using Blipped-CAIPI based EPI readout. It has been shown that this technique can expedite ASL imaging acquisition, improve image coverage and/or resolution with little penalty or even gain in SNR. Another advantage of MB acquisition for ASL is shortened T1 relaxation of the label, which degrades ASL signal in conventional sequential 2D EPI readout. However, MB EPI still suffers from susceptibility, N/2 ghosting and other distortion artifacts, especially at high and ultrahigh magnetic fields. In this work, we present a MB turbo-FLASH based pseudo-continuous ASL sequence that is able to provide whole-brain distortion-free perfusion images at both 3 and 7T.

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