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Abstract #2705

Comparison of Transit Delay Sensitivity between Pseudo-Continuous ASL, Pulsed ASL and Velocity-Selective ASL

Jia Guo 1 and Eric C. Wong 2

1 Bioengineering, UC San Diego, La Jolla, California, United States, 2 Radiology and Psychiatry, UC San Diego, California, United States

Transit delay (TD) sensitivity remains the main source of error in local CBF quantification using ASL. Compared with PASL and PCASL, Velocity-Selective ASL (VSASL) labels spins on the basis of flow velocity instead of location. In theory, VSASL eliminates the gap between the tagging and imaging regions and the associated long and heterogeneous TDs. However, it has not been verified by direct measurement of TDs in VSASL. This study is the first one to provide direct experimental evidences of VSASL being insensitive to TD, in contrast to PASL and PCASL. The averaged TDs of PCASL, PASL and VSASL were 1.280.28s (meanstd), 1.090.28s and 0.240.07s respectively, via multi-TI experiments.

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