Globally Correlated Brain Signals Using Resting State Arterial Spin Labeling

Brain resting state fluctuation networks has been reported contributing to the variability in Arterial Spin Labeling (ASL) measurements. However, a larger, globally correlated fluctuation appears to be the greatest contributor. Here we employ cardiac and respiratory cycle measurements during repeated ASL measurements to assess the systemic physiologic contribution to ASL fluctuations and to separate them from fluctuations with more brain specific origins. Five healthy volunteers were scanned using resting state ASL imaging with physiological monitoring of cardiac and respiratory signals. Global ASL signals was associated with cardiac phase but not with respiratory phase. After removing the cardiac noise, a large globally correlated fluctuation still exists, suggesting the presence of a global brain network independent of other resting state networks.

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