Abstract #2707
Globally Correlated Brain Signals Using Resting State Arterial Spin Labeling
Weiying Dai 1 , Ajit Shankaranarayanan 2 , and David Alsop 1
1
Radiology, Beth Israel Deaconess Medical
Center & Harvard Medical School, Boston, MA, United
States,
2
Global
Applied Science Laboratory, GE Healthcare, Menlo Park,
CA, United States
Brain resting state fluctuation networks has been
reported contributing to the variability in Arterial
Spin Labeling (ASL) measurements. However, a larger,
globally correlated fluctuation appears to be the
greatest contributor. Here we employ cardiac and
respiratory cycle measurements during repeated ASL
measurements to assess the systemic physiologic
contribution to ASL fluctuations and to separate them
from fluctuations with more brain specific origins. Five
healthy volunteers were scanned using resting state ASL
imaging with physiological monitoring of cardiac and
respiratory signals. Global ASL signals was associated
with cardiac phase but not with respiratory phase. After
removing the cardiac noise, a large globally correlated
fluctuation still exists, suggesting the presence of a
global brain network independent of other resting state
networks.
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