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Abstract #2712

Consistency Checks for Partial Volume Correction of ASL perfusion maps

Joost P.A. Kuijer 1 , Alexandra De Sitter 1 , Maja A.A. Binnewijzend 2 , Frederik Barkhof 2 , and Rudolf M. Verdaasdonk 1

1 Physics and Medical Technology, VU University Medical Center, Amsterdam, NH, Netherlands, 2 Radiology, Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, NH, Netherlands

Partial volume correction (PVC) is regularly applied to quantify the cerebral perfusion of grey and/or white matter. PVC methods are usually validated with simulated datasets, however these might not model all aspects of real ASL data. In this study two checks are proposed to evaluate a PVC method: downsampling or spatial low-pass filtering of both perfusion and PVE maps should not alter the perfusion for each tissue type. These checks were applied to ASL data of six healthy volunteers and the linear regression PVC method. While the simulated data suggest a proper PVC, real ASL data fail the proposed check.

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