Abstract #2712
Consistency Checks for Partial Volume Correction of ASL perfusion maps
Joost P.A. Kuijer 1 , Alexandra De Sitter 1 , Maja A.A. Binnewijzend 2 , Frederik Barkhof 2 , and Rudolf M. Verdaasdonk 1
1
Physics and Medical Technology, VU
University Medical Center, Amsterdam, NH, Netherlands,
2
Radiology,
Nuclear Medicine and PET Research, VU University Medical
Center, Amsterdam, NH, Netherlands
Partial volume correction (PVC) is regularly applied to
quantify the cerebral perfusion of grey and/or white
matter. PVC methods are usually validated with simulated
datasets, however these might not model all aspects of
real ASL data. In this study two checks are proposed to
evaluate a PVC method: downsampling or spatial low-pass
filtering of both perfusion and PVE maps should not
alter the perfusion for each tissue type. These checks
were applied to ASL data of six healthy volunteers and
the linear regression PVC method. While the simulated
data suggest a proper PVC, real ASL data fail the
proposed check.
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