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Abstract #2718

Assessment of Water Diffusion Compartmentation in the Non-Human Primate Brain

Ramesh Paudyal 1 , Chun-Xia Li 1 , Edward J. Auerbach 2 , and Xiaodong Zhang 1

1 Yerkes Imaging Center, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA, United States, 2 Center for MR Research, University of Minnesota, MN, United States

Arterial spin labeling (ASL) can be used to study stroke and other cerebrovascular diseases. Biexpoential fit to the signal decay data arising from the vascular and tissue compartments acquired using a modified diffusion weighted (DW) - ASL perfusion technique yields the fast and slow diffusion components and their respective volume fractions. In this study, we demonstrated the differences in the fitted parameter in both the slow and fast diffusing components in the white and gray matter in non-human brain primates using diffusion weighted (DW) - ASL perfusion data.

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