Abstract #2725
Repeatability and Variability of Pre-Clinical Hepatic Arterial Spin Labelling
Rajiv Ramasawmy 1,2 , Adrienne E. Campbell-Washburn 3 , Sean Peter Johnson 1 , Jack Anthony Wells 1 , Rosamund Barbara Pedley 2 , Mark Francis Lythgoe 1 , and Simon Walker-Samuel 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, Greater London,
United Kingdom,
2
Cancer
Institute, University College London, London, Greater
London, United Kingdom,
3
National
Heart Lung and Blood Institute, National Institutes of
Health, Bethesda, MD, United States
Hepatic ASL (hASL) is an emerging area of research
interest. We present repeatability and variability
analysis of a respiratory-triggered flow-sensitive
alternating inversion recovery (FAIR) Look-Locker
arterial spin labelling (ASL) technique to measure mouse
liver perfusion. To evaluate the liver ASL technique,
repeatability and variability statistics were produced
for repeat measurements within a single imaging session
and between imaging sessions separated by one week. We
show that the repeatability of the technique is
potentially sufficient to allow longitudinal monitoring
of pre-clinical liver perfusion in models of diseases
such as cancer and cirrhosis.
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