Abstract #2730
Advanced Analysis of USPIO Injection in Normal Volunteers
Thomas Christen 1 , Deqiang Qiu 1 , Wendy Wei Ni 1 , Heiko Schmiedeskamp 1 , Michael E Moseley 1 , and Greg Zaharchuk 1
1
Department of Radiology, Stanford
University, Stanford, California, United States
It has been recently suggested that following a bolus of
contrast agent (CA) with a combined spin- and
gradient-echo sequence can bring valuable information
about vessel architecture and oxygenation. While
promising, the approach might however suffer from low
signal to noise ratio as well as contrast agent leakage
if a gadolinium based CA is used. As an alternative, we
propose to follow an injection of ferumoxytol, an
FDA-approved ultra-small paramagnetic iron oxide (USPIO)
compound. We scanned 10 volunteers to study the
feasibility of approach and combined the results with
bolus perfusion and quantitative BOLD analyses.
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