Tracer-kinetic field analysis in DCE-MRI and DSC-MRI: theory and examples

Conventional tracer-kinetic analysis of DSC- and DCE-MRI assumes that all voxels are isolated systems supplied by the same arterial concentration. Here a more general tracer-kinetic field theory is developed that models voxels as interconnected systems that only exchange indicator with their immediate neighbours. Explicit field models are derived for total blood flow, microvascular blood flow, endothelial permeability and interstitial diffusion. With these models, the spatial structure of the measured concentration can be exploited to characterize perfusion anisotropy, and to eliminate systematic errors due to bolus dispersion and large-vessel contamination.

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