Abstract #2738
Joint estimation of precontrast T 1 and DCE-MRI perfusion and permeability parameters significantly improves precision of parameter estimates
Ben R Dickie 1 , Anita Banerji 2,3 , Catharine M West 4 , and Chris J Rose 2,3
1
Christie Medical Physics and Engineering,
Christie Hospital, Manchester, Greater Manchester,
United Kingdom,
2
Centre
for Imaging Sciences, Manchester Academic Health Science
Centre, University of Manchester, Manchester, United
Kingdom,
3
Biomedical
Imaging Institute, University of Manchester, Manchester,
United Kingdom,
4
Institute
of Cancer Sciences, University of Manchester,
Manchester, United Kingdom
A novel method for estimating DCE-MRI parameters is
presented. Precontrast T1, M0, and model parameters are
estimated jointly, differing from current practice where
precontrast T1 and M0 are estimated prior to the model
parameters (sequentially). The precision of the two
methods were compared using a software phantom capable
of simulating realistic abdominal anatomy, contrast
enhancement (as modelled with the two-compartment
exchange model) and non-linear local motion. Joint
estimation led to significant improvements in the
precision for all model parameters. In data with motion
corruption, significant improvements in precision were
observed for estimates of plasma perfusion and relative
interstitial volume only.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
