Investigation of Weighted Fits applied to Compartment Models of Dynamic Contrast Enhanced Magnetic Resonance Imaging

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in conjunction with pharmacokinetic modelling can be used to assess physiological parameters like perfusion and permeability. The aim of this study was to investigate the effect of weighted fits applied to DCE-MRI data, using both simulated and measured samples, and the overall goal was to quantify if weighting leads to a better fit performance.It could be shown that in most of the studied tissues the errors of the fit parameters decreased when linear weights were applied. Initial results of the in vivo data of the rat shown made clear that weighting has a small but positive effect on the fit performance in living tissue

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