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Abstract #2742

Precision of two-compartment exchange model parameter estimates: dependence on tissue physiology

Ben R Dickie 1 , Catharine M West 2 , and Chris J Rose 3,4

1 Christie Medical Physics and Engineering, Christie Hospital, Manchester, Greater Manchester, United Kingdom, 2 Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 3 Centre for Imaging Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 4 Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom

The two-compartment exchange model can be fitted to DCE-MRI signal-time curves yielding estimates of plasma flow (Fp), plasma-interstitial exchange flow (FE) and relative plasma volume (vp) and relative interstitial volume (ve). The precision of these estimates is not likely to be uniform for all tissue types and this variation has not been studied in the literature. We present an evaluation of such errors for data with SNR of 5 and temporal resolution of 2.5s and show that as the plasma flow of the tissue of interest decreases below 0.1 ml/ml/min, relative errors in Fp and FE begin to rapidly increase.

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