Precision of two-compartment exchange model parameter estimates: dependence on tissue physiology
Ben R Dickie 1 , Catharine M West 2 , and Chris J Rose 3,4
Christie Medical Physics and Engineering,
Christie Hospital, Manchester, Greater Manchester,
of Cancer Sciences, University of Manchester,
Manchester, United Kingdom,
for Imaging Sciences, Manchester Academic Health Science
Centre, University of Manchester, Manchester, United
Biomedical Imaging Institute,
University of Manchester, Manchester, United Kingdom
The two-compartment exchange model can be fitted to DCE-MRI
signal-time curves yielding estimates of plasma flow (Fp),
plasma-interstitial exchange flow (FE) and relative
plasma volume (vp) and relative interstitial volume (ve).
The precision of these estimates is not likely to be
uniform for all tissue types and this variation has not
been studied in the literature. We present an evaluation
of such errors for data with SNR of 5 and temporal
resolution of 2.5s and show that as the plasma flow of
the tissue of interest decreases below 0.1 ml/ml/min,
relative errors in Fp and FE begin to rapidly increase.
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