Effect of k-Space Weighted Image Contrast with golden-angle view ordering on diagnostic accuracy for lesion discrimination

In this study, we quantitatively evaluate temporal blurring of DCE-MRI data sets generated using a k-space weighted image contrast image sharing technique with golden-angle view ordering (GA-KWIC) by examining the effect on estimated pharmacokinetic model parameters in simulation. Estimated Ktrans values have a larger bias for smaller lesions and higher true Ktrans values, resulting in errors in estimated diagnostic accuracy for discrimination of benign and malignant lesions. However, the errors incurred are small compared to other sources of error in clinical studies. Therefore, GA-KWIC can be used to improve temporal resolution of DCE-MRI data without negatively impacting diagnostic accuracy estimation.

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