Abstract #2755
Dynamic Contrast-enhanced MRI Perfusion in a Unilateral Ureteral Obstruction (UUO) Mouse Model
Wei Zha 1 , David J. Niles 1 , Shannon Reese 2 , Arjang Djamali 2 , and Sean B. Fain 1
1
Medical Physics, University of
Wisconsin-Madison, Madison, WI, United States,
2
Medicine,
University of Wisconsin-Madison, WI, United States
Quantitative renal perfusion is promising for the
diagnosis and prognosis of kidney function. This study
used DCE-MRI to monitor renal perfusion changes during
obstructive nephropathy in a 7-day unilateral ureteral
obstruction mouse model. A 3-compartmental model was
used to quantify the tissue perfusion with gamma-variate
curve fitting. Decreased cortical perfusion was found in
the obstructed kidney in both NADPH oxidase isoform2
(NOX2) knock out (KO) and wild-type (WT) mice on Day 7.
Results suggest the alteration in renal perfusion may be
an early, sensitive indicator of the progression of
renal fibrosis.
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