Abstract #2759
Combined evaluation of 18 F-FDG PET Metabolic Parameters and MRI Perfusion Parameters for the Prediction of Neoadjuvant Chemotherapy Response in Osteosarcoma
In ok Ko 1 , Byung Hyun Byun 2 , Ji-ae Park 1 , Kyeong Min Kim 1 , and Sang Moo Lim 2
1
Korea Institute of Radiological & Medical
Science, seoul, nowon-gu, Korea, Democratic People's
Republic of,
2
Department
of Nuclear Medicine, Korea Institute of Radiological &
Medical Science, seoul, nowon-gu, Korea, Democratic
People's Republic of
We evaluated the potentials of 18F-FDG PET metabolic
parameters and dynamic contrast-enhanced (DCE) MRI
perfusion parameters to predict the histologic response
after neoadjuvant chemotherapy before surgery in
patients with osteoscarcoma, using sequential PET/CT and
MR imaging system. The cutoff values, sensitivity,
specificity, and accuracy for predicting good histologic
response were < 5, 92%, 58%, and 75%, respectively, for
SUV
max
from
the 18F-FDG PET after neoadjuvant chemotherapy and <
0.03 min-1, 58%, 83%, and 71%, respectively, for K
trans
from
the DCE-MRI after neoadjuvant chemotherapy. By using the
combined criterion of SUV
max
<
5 and K
trans
<
0.03 min
-1
, sensitivity, specificity, and
accuracy were 67%, 100% and 84%, respectively. Our
results suggest that combining 18F-FDG PET metabolic
parameters and DCE-MRI perfusion parameters should be an
effective method to predict the histologic response to
NAC in osteosarcoma.
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