Development of a Novel 2DRF Pulse Sequence to Achieve Improved Localization in Hyperpolarized 13 C Imaging

Hyperpolarization of metabolically active compounds labeled with ¹³ C is an emerging approach for imaging metabolic processes in vivo. We designed a new two-dimensional spatially-selective radiofrequency (2DRF) pulse for bolus tracking in hyperpolarized ¹³ C imaging. Advantages of applying 2DRF in hyperpolarized ¹³ C imaging include reducing polarization loss and shortening acquisition time. Due to the use of a spiral excitation trajectory, our design allows for minimal perturbation of other off-resonance metabolites. Since our 2DRF pulse was developed for a 3T clinical scanner with conventional gradient performances, rapid translation of our design to human studies is possible.

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