Abstract #2773
Survival from Brain Metastasis of Breast Cancer is Inversely Correlated with Hyperpolarized 1-13C Lactate/Pyruvate ratio: Preliminary Study in Nude Mouse Model.
Young-suk Choi 1 , Joon-Sung Lee 2,3 , Han-Sol Lee 3 , Hyun-Jin Park 1 , Ju-Hyun Lee 1 , Eun-Kyung Wang 1 , Seung-Wook Yang 3 , Eun-Hae Joe 3 , Dong-Hyun Kim 3 , and Ho-Taek Song 1
1
Department of Radiology, Yonsei University
College of Medicine, Seodaemun-Gu, Seoul, Korea,
2
SIRIC,
Yonsei University College of Medicine, Seodaemun-Gu,
Seoul, Korea,
3
Department of Eletrical &
Electronic Engineering, Yonsei University, Seodaemun-Gu,
Seoul, Korea
In brain metastasis from breast cancer mouse model, we
evaluate the pyruvate to lactate conversion ratio to
monitor the alteration of metabolism by metformin by
hyperpolarized 13C metabolic MRS imaging. The inhibition
of tumor growth by metformin was not proved by
conventional imaging and hyperpolarized 13C MRSI.
Individual conversion ratio of 13C pyruvate to 13C
lactate showed inverse correlation with survival
regardless of experimental group. Hyperpolarized 13C
MRSI may be useful tool to predict the prognosis cancer
patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
