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Abstract #2781

PHIP of valproic acid and related structures

Thomas Trantzschel 1 , Denise Lego 2 , Markus Plaumann 1 , Grit Sauer 3 , Torsten Gutmann 3 , Joachim Bargon 4 , Gerd Buntkowsky 3 , Johannes Bernarding 1 , and Ute Bommerich 2

1 Department for Biometry and Medical Informatics, Otto-von-Guericke Univeritt Magdeburg, Magdeburg, Germany, 2 Leibniz Institute for Neurobiology, Magdeburg, Germany, 3 Eduard-Zintl-Institute for Inorganic Chemistry, Technical University Darmstadt, Darmstadt, Germany, 4 Institute of Physical and Theoretical Chemistry, Bonn, Germany

Parahydrogen Induced Polarization (PHIP) is increasingly used as a promising tool for medical/biological applications in magnetic resonance as it can increase MR-sensitivity by orders of magnitude. So far only a few number of molecules acting as metabolic sensors were already hyperpolarized with PHIP, but the direct hyperpolarization of drugs used in the treatment of neurological disorders was not achieved so far. In this study the feasibility of applying PHIP to valproate (used in epilepsy treatment) and structurally related molecules with different side chains was examined in NMR and MRI experiments.

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