A Multi-compartment Phantom for Controlled and Heterogeneous Conversion of Hyperpolarized [1-13C]-Pyruvate to Lactate

One barrier to efficient development and validation of advanced imaging techniques for hyperpolarized agents is then current lack of a practical model for the complex biology probed by hyperpolarized MR. To fill this need we propose a multi compartment single enzyme phantom that allows repeatable conversion of pyruvate to lactate in a tunable manner for mimicking different tissue states. We have demonstrated the phantoms spatial dependence with both multichannel spectral measurements and cumulative spectral Imaging. This platform has the potential to speed development and implementation of complex imaging strategies for efficient hyperpolarized MR.

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