Bovine Serum Albumin (BSA) as Ultrasmall Nanoparticles Carrier: Application to MRI Contrast Agents

Biological molecules are suitable carriers of ultrasmall nanoparticles for biomedical applications. In this study, we investigate: (1) BSA is a good nanoparticles carrier (2) MR relaxivity measurements revealed that BSA-PEG diacid-ultrasmall Gadolinium oxide nanoparticles (BSA-PEGD-GNPs) had larger r1 and r2 values than those of the molecular Gd-chelates (3) The 3 tesla T2 MR images after injecting the aqueous sample solution of BSA-PEGD-GNPs into the mouse tail vein showed clear negative contrast enhancements, confirming that the sample solution functioned as a T2 MRI contrast agent

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