Abstract #2850
Synthesis and characterization of multi-layered hybrid gold-iron oxide superparamagnetic nanoparticles.
Alexei Bogdanov, Jr 1 , Mohammed S Shazeeb 1 , Lejie Zhang 2 , and Surong Zhang 1
1
Radiology, UMASS Medical School, Worcester,
MA, United States,
2
Biochemical
Pharmacology, UMASS Medical School, Worcester, MA,
United States
We developed a strategy enabling synthesis of hybrid
iron-oxide gold nanoparticles with very high molar
relaxivity in water. Silver-tagged dextran-stabilized
iron oxides (IO-Ag) were formed by reacting iron oxides
in the presence of diamminesilver(I) nitrate. Incubation
of IO-Ag in the presence of tetrachloroauric acid and
citrate resulted in the formation of electron dense
single-core negatively charged IO-Ag-Au which were
stabilized using MPEG-gPLL resulting in stable 65 nm
nanoparticles. At 3T, the increase of r2 allowed
improving the detectability level by a factor of 10. The
obtained nanoparticles could be targeted using antibody
fragments and were forming complexes with
oligonucleotide duplexes.
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