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Abstract #2860

Microfabricated High-moment Iron Particles for In Vivo Cell Tracking

Stephen Dodd 1 , Gary Zabow 1,2 , Nikorn Pothayee 1 , John Moreland 2 , and Alan Koretsky 1

1 Laboratory of Functional and Molecular Imaging, NINDS, National Institutes of Health, Bethesda, MD, United States, 2 Physical Measurements Division, NIST, Boulder, Colorado, United States

A demonstration of micro-fabricated gold-coated iron particles, 1 m in diameter for an in vivo experiment is presented. These particles have a higher moment than iron-oxide based particles, and offer greater contrast for a single particle in a smaller volume. The fabrication process is briefly described, and single particle contrast is shown in phantom images. After injection into the lateral ventricle, particles were shown to track from the subventricular zone to the olfactory bulb in the rat brain, with contrast still observed after 6 weeks.

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