Abstract #2860
Microfabricated High-moment Iron Particles for In Vivo Cell Tracking
Stephen Dodd 1 , Gary Zabow 1,2 , Nikorn Pothayee 1 , John Moreland 2 , and Alan Koretsky 1
1
Laboratory of Functional and Molecular
Imaging, NINDS, National Institutes of Health, Bethesda,
MD, United States,
2
Physical
Measurements Division, NIST, Boulder, Colorado, United
States
A demonstration of micro-fabricated gold-coated iron
particles, 1 m in diameter for an
in
vivo
experiment
is presented. These particles have a higher moment than
iron-oxide based particles, and offer greater contrast
for a single particle in a smaller volume. The
fabrication process is briefly described, and single
particle contrast is shown in phantom images. After
injection into the lateral ventricle, particles were
shown to track from the subventricular zone to the
olfactory bulb in the rat brain, with contrast still
observed after 6 weeks.
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