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Abstract #2891

Simultaneous measurement of pH, lactate and acetyl-carnitine in skeletal muscle at 7T

Jimin Ren 1 , A. Dean Sherry 1,2 , and Craig R. Malloy 1,3

1 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, United States, 2 University of Texas at Dallas, Texas, United States, 3 VA North Texas Health Care System, Texas, United States

For a long time, muscle acidification and accumulation of lactate and acetyl groups have been measured either invasively by biopsies or noninvasively by separate MRS techniques targeting on each individual metabolites. The current study was designed to monitor exercise-induced changes in pH, lactate and acetyl-carnitine in human skeletal muscle using a single localized 1H MRS protocol, with pH reported by carnosine imidazole H4 signal, lactate by its methine signal at 4. 1 ppm and acetyl-carnitine by its acetyl signal at 2.12 ppm. This technique provides an easy access to important metabolic information on multiple pathways in skeletal muscle in vivo.

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