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Abstract #2895

Optimisation of asymmetric adiabatic pulses for single voxel metabolite cycled 1 H-MRS in the human brain at 9.4 Tesla

Ioannis Angelos Giapitzakis 1 , Tingting Shao 1 , Nikolai Avdievich 1 , Roland Kreis 2 , and Anke Henning 1,3

1 Dept. of High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tbingen, Baden-Wrttemberg, Germany, 2 Departments of Radiology and Clinical Research, University of Bern, Bern, Switzerland, 3 Institute for Biomedical Engineering, University and ETH Zrich, Zrich, Switzerland

Asymmetric adiabatic pulses have been used for metabolite cycled 1H-MRS at 3 Tesla and 7 Tesla enabling better spectral resolution and post-processing of the measured data without scan time prolongation. In this abstract, the frequency excitation profile of the adiabatic pulses was extensively studied with regards to time duration, the B 1 + field and the frequency sweep range. Optimum values for the characteristics of the inversion pulses were found for implementation in a STEAM sequence at 9.4T. Both phantom and in vivo measurements on a healthy volunteer verified the simulations and showed that metabolite cycled 1H-MRS is feasible at 9.4T.

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