Time Course Study on Glucose Metabolism in Mice by Spectroscopic Imaging with 2D Heteronuclear Multiple Quantum Coherence

We demonstrate the feasibility of a ¹ H- ¹³ C heteronuclear multiple quantum coherence (HMQC) MRSI for imaging metabolite dynamics. The ¹ H- ¹³ C HMQC MRSI was performed for the whole-body acquisition of four tumor-bearing mice after sacrifice at 5min, 8min, 30min, and 20hr post injection of [U- ¹³ C]glucose. Form acquired 4D data set (two spectral and two spatial dimensions), the signal intensity ratio of lactate (Lac) to glucose (Glc) was mapped. When focusing on the tumor, the Lac/Glc value increased with time, reflecting the accumulation of Lac as a metabolic end product from Glc in the tumor.

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