Meeting Banner
Abstract #2935

Cerebral Phosphorus Metabolites Profiling of Parkinsons Disease Patients at 7T

Xiao-Hong Zhu 1 , Byeong-Yeul Lee 1 , Susan Rolandelli 2 , Paul Tuite 2 , and Wei Chen 1

1 CMRR, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, 2 Department of Neurology, University of Minnesota Medical School, MN, United States

Parkinsons disease (PD) is the second most common neurodegenerative disorder, which affects men slightly more often than women. Mitochondrial dysfunction has been suspected as a pathogenic mechanism of PD. However, direct in vivo evidence of mitochondrial abnormalities and accompanying impairments in energy metabolism is incomplete in PD. Fortunately with developments of in vivo 31 P MRS at 7 tesla, it is now possible to obtain high quality quantitative cerebral phosphorus metabolite profiles which give insight into brain metabolism. In our evaluation of individuals with PD and matched controls we demonstrated significant differences between male and female PD subjects in the phosphorus metabolite profiles. These preliminary findings highlight the feasibility of this non-invasive MR method that may further understanding of PD as well as potential gender effects on the disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here