Alterations of GABA levels in premenstrual syndrome women: A proton magnetic resonance spectroscopy study.

Most women of reproductive age suffer from premenstrual syndrome(PMS) ,which is affecting their daily life .Evidences have shown the involvement of gamma-aminobutyric acid(GABA) neurotransmitter system in PMS. In this study , significantly reduced GABA levels were observed in PMS women in the anterior cingulate cortex (ACC)/medial prefrontal cortex (mPFC) ,whereas no difference was found in ltBG. The ACC/mPFC was suggested to be involved in negative emotions and in modulation of automatic nervous systems, and dysfunctions in this region may partly underlie the variety of psychosomatic premenstrual symptoms. Premenstrual GABA deficit may be an important neurobiological mechanism contributing to the pathophysiology of PMS.

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