GABA correlates differently with fMRI activation volume and BOLD signal in noisy datasets

Correlating cerebral gamma amino butyric acid (GABA) level with fMRI activation is of recent research interest. As a quantitation of fMRI activation, different investigators have used (i) activation volume within a region of interest, or (ii) amplitude of blood oxygen level dependent (BOLD) signal change. Robustness of activation volume in comparison with BOLD signal change was recently reported. We compared GABA level correlation with both fMRI activation volume and BOLD signal change, and demonstrate that for a population with higher variablity in noise (as in patients with multiple sclerosis), activation volume is a more sensible metric of fMRI activation.

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