Abstract #2943
GABA correlates differently with fMRI activation volume and BOLD signal in noisy datasets
Pallab K Bhattacharyya 1 , Blessy Mathew 1 , Robert Bermel 1 , Micheal Phillips 1 , Lael Stone 1 , and Mark Lowe 1
1
Cleveland Clinic, Cleveland, OH, United
States
Correlating cerebral gamma amino butyric acid (GABA)
level with fMRI activation is of recent research
interest. As a quantitation of fMRI activation,
different investigators have used (i) activation volume
within a region of interest, or (ii) amplitude of blood
oxygen level dependent (BOLD) signal change. Robustness
of activation volume in comparison with BOLD signal
change was recently reported. We compared GABA level
correlation with both fMRI activation volume and BOLD
signal change, and demonstrate that for a population
with higher variablity in noise (as in patients with
multiple sclerosis), activation volume is a more
sensible metric of fMRI activation.
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