Abstract #2945
Establishing a Method of 23 Na - Imaging after Blood Brain Barrier Disruption
Andreas Neubauer 1 , Awais Akbar Bajwa 2 , Michaela Ruttorf 1 , Michael Schwerter 1 , Lothar Schilling 2 , and Lothar Schad 1
1
Computer Assisted Clinical Medicine, Medical
Faculty Mannheim, Heidelberg University, Mannheim,
Baden-Wuertemberg, Germany,
2
Division
of Neurosurgical Research, Medical Faculty Mannheim,
Heidelberg University, Mannheim, Baden-Wuertemberg,
Germany
Tracking pathological processes
in
vivo
is
still of great interest in clinical research. Therefore,
23
Na
- MRI has become a useful tool to monitor the total
sodium concentration in brain tissue. Unfortunately,
conventional techniques are not capablo to resolve
changes in intra- and extracellular sodium reliably. In
this study, we present a method to transiently open the
blood
brain barrier
and
load the brain tissue with the sodium shift agent
Tm[DOTP]
5-
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