Abstract #2964
Region-specific cerebral metabolic changes in streptozotocin-induced T1DM rats revealed by in vivo 1 H-MRS
Hui Zhang 1 , Mingming Huang 2 , Lifeng Gao 1 , and Hao Lei 1
1
State Key Laboratory of Magnetic Resonance
and Atomic and Molecular Physics, Wuhan Institute of
Physics and Mathematics, Chinese Academy of Sciences,
Wuhan, Hubei, China,
2
Guiyang
Medical University, Guiyang, Guizhou, China
In this work, we used in vivo
1
H
MRS to measure metabolic changes in the striatum,
hippocampus and visual cortex of streptozotocin
(STZ)-induced T1DM rats at 4 weeks after induction. We
found that, for STZ-treated animals, Glu, NAA and tNAA
levels were significantly lower than control in striatum
and hippocampus, but not in visual cortex. Tau and Ins
levels were significantly higher only in hippocampus,
but not in striatum and visual cortex; Glx remained
unchanged in all three regions. Our results suggested
that the metabolic alterations in the brain of
STZ-induced T1DM are region-specific.
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