Simulation of BOLD Sensitivity of Single-Shot Multi-Echo EPI versus Sample-Induced Susceptibility Gradients

For functional MRI, the use of a single-shot multi-echo EPI (MEPI) has been shown to be an advantageous acquisition scheme. Among others factors, MEPI increases fMRI BOLD sensitivity and offers increased robustness to sample-induced susceptibility gradients. In addition, parallel imaging has been shown to significantly reduce EPI distortions but suffers from SNR loss. However, the limit of BOLD sensitivity as a function of the susceptibility gradients is unknown. Here, we investigate the BOLD sensitivity as a function of the susceptibility gradients using simulations and considering a MEPI acquisition protocol with a high acceleration factor, and an echo combination method.

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