Respiratory Volume Over Time Effects in Resting-State Gradient-Echo and Spin-Echo EPI BOLD

This study investigated the effects of respiratory noise on gradient-echo vs. spin-echo BOLD acquired in the resting-state. Correlations were calculated between gradient-/spin-echo scans and the raw respiration volume over time signal as well as this same signal convolved with a respiration response function. Spin-echo showed weaker and less structured correlations to the respiration volume over time signal, supporting the idea that the effects of this signal are more prominent in gradient-echo scans and have a potential macrovascular origin. The findings presented here further support the benefits of using spin-echo BOLD as an alternative in resting-state functional MRI studies.

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