Impacts of Single Carrier Wideband Gradient-Echo Sequence in BOLD Contrast
Shih-Hsien Yang 1 , Yun-An Huang 2 , Tzu-Hao Harry Chao 3 , Der-Yow Chen 4 , Kuan-Hung Cho 5 , Li-Wei Kuo 6 , Jyh-Horng Chen 2 , and Changwei W. Wu 1
Graduate Institute of Biomedical
Engineering, National Central University, Taoyuan,
of Electrical Engineering, National Taiwan University,
of Life Science, National Taiwan University, Taipei,
of Psychology, National Cheng Kung University, Tainan,
of Brain Science, National Yang-Ming University, Taipei,
of Biomedical Engineering and Nanomedicine, National
Health Research Institutes, Miaoli, Taiwan
The blood-oxygenation-level-dependent (BOLD) fMRI has
been widely implemented to study brain functions.
However, the BOLD contrast still suffers the low
temporal resolution and low sensitivity. Here, we
applied single carrier Wideband (WB) MRI technique on
gradient echo imaging (GRE) sequence in fMRI studies, in
order to reduce the scan time and enhance the T2*
sensitivity. By examining the simulated BOLD contrast
from different inhaled gas, this study demonstrated the
reduced scan time and enhanced sensitivity of the
Wideband MRI technique.
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