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Abstract #3005

Brain activation and paralimbic-limbic cortex functional connectivity during human slow wave sleep: an fMRI study

Jun Lv 1 , Dongdong Liu 2 , Jing Ma 3 , JUE ZHANG 1,2 , Xiaoying Wang 1,4 , and Jing Fang 1,2

1 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, Beijing, China, 2 College of Enigneering, Peking University, Beijing, Beijing, China, 3 Dept. of Pulmonary Medicine, Peking University First Hospital, Beijing, China, 4 Dept. of Radiology, Peking University First Hospital, Beijing, Beijing, China

Graph theoretical analysis of functional magnetic resonance imaging (fMRI) time series has revealed a small-world organization of slow-frequency blood oxygen level dependent (BOLD) signal fluctuations during wakeful resting. The purpose of this study was to use this approach to explore the changes of paralimbic-limbic cortex during slow wave sleep which are reflected in small-world properties and functional connectivity of our brain network. Our result suggested that paralimbic-limbic cortex was getting more independent when human sleep. It means that our brain owns a kind of defense mechanism responsible for suppressing the external environment interference which may strongly explain why sleep insufficiency has adverse impact on memory. Thus, our study provides a new insight for revealing the significance of sleep on memory process.

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