Abstract #3005
Brain activation and paralimbic-limbic cortex functional connectivity during human slow wave sleep: an fMRI study
Jun Lv 1 , Dongdong Liu 2 , Jing Ma 3 , JUE ZHANG 1,2 , Xiaoying Wang 1,4 , and Jing Fang 1,2
1
Academy for Advanced Interdisciplinary
Studies, Peking University, Beijing, Beijing, China,
2
College
of Enigneering, Peking University, Beijing, Beijing,
China,
3
Dept.
of Pulmonary Medicine, Peking University First Hospital,
Beijing, China,
4
Dept.
of Radiology, Peking University First Hospital, Beijing,
Beijing, China
Graph theoretical analysis of functional magnetic
resonance imaging (fMRI) time series has revealed a
small-world organization of slow-frequency blood oxygen
level dependent (BOLD) signal fluctuations during
wakeful resting. The purpose of this study was to use
this approach to explore the changes of paralimbic-limbic
cortex during slow wave sleep which are reflected in
small-world properties and functional connectivity of
our brain network. Our result suggested that paralimbic-limbic
cortex was getting more independent when human sleep. It
means that our brain owns a kind of defense mechanism
responsible for suppressing the external environment
interference which may strongly explain why sleep
insufficiency has adverse impact on memory. Thus, our
study provides a new insight for revealing the
significance of sleep on memory process.
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