Abstract #3014
Working memory deficit in children treated for cerebellar medullobastoma: An fMRI study
Duc Ha Hoang 1 , Anne Pagnier 2 , Emilie Cousin 3 , Karine Guichardet 2 , Isabelle Schiff 2 , Fanny Dubois-Teklali 2 , and Alexandre Krainik 4
1
Grenoble Institute of Neurosciences,
Grenoble, France,
2
Department
of Pediatrics - Grenoble University Hospital, Grenoble,
France,
3
Laboratoratory
of Psychology and Neurocognition - University Pierre
Mendès, Grenoble, France,
4
Department
of Neuroradiology and MRI - Grenoble University
Hospital, Grenoble, France
Survivors with medulloblastoma demonstrated working
memory (WM) deficit, leading to an impairment of school
performance. The purpose is to describe the cerebellar
involvement in specific cognitive deficits observed in
children with medulloblastoma • 9 healthy volunteers
children and 5 patients with cerebellar medulloblastoma.
Using BOLD fMRI, SPM8 • 4/5 patients had a WM deficit
following a resection of left posterior cerebellar lobe
(CrusI/II, lobule VIIb/VIII) and inferior vermis; the
only patient without WM deficit was the only one without
cerebellar hemispheric lesion. BOLD activations were
found in the left posterior cerebellar lobe • The left
posterior cerebellar lobe may involve the visuospatial
WM
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