The interaction of APOE genotype by Age in amnestic mild cognitive impairment: a voxel-based morphometric study
Jiu Chen 1 and Zhi-jun Zhang 1
Neurologic Department, Affiliated ZhongDa
Hospital, Neuropsychiatric Institute and Medical School
of Southeast University, nanjing, jiangsu, China
The study showed that amnestic mild cognitive impairment
(aMCI) had the deficits of gray matter (GM) volume on
the network of cerebellum-limbic system, and suggests an
apolipoprotein E (APOE)-specific effect of age with GM
volume on the occipito-insula-frontal neural circuit.
Moreover, the results suggest that GM deficits could be
accelerated by the combined effect of the aging process
and the presence of the APOE 4 allele. Conversely, the
APOE 2 possibly reflects a protective morphometric
main effect, which increases with age in aMCI. The
relationship of GM alterations with neuropsychological
test supported that GM atrophy was the basis of
cognitive impairment in aMCI.
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