The interaction of APOE genotype by Age in amnestic mild cognitive impairment: a voxel-based morphometric study

The study showed that amnestic mild cognitive impairment (aMCI) had the deficits of gray matter (GM) volume on the network of cerebellum-limbic system, and suggests an apolipoprotein E (APOE)-specific effect of age with GM volume on the occipito-insula-frontal neural circuit. Moreover, the results suggest that GM deficits could be accelerated by the combined effect of the aging process and the presence of the APOE 4 allele. Conversely, the APOE 2 possibly reflects a protective morphometric main effect, which increases with age in aMCI. The relationship of GM alterations with neuropsychological test supported that GM atrophy was the basis of cognitive impairment in aMCI.

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