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Abstract #3018

Self-regulation of rACC activation in patients with Postherpetic Neuralgia:A preliminary study using Real-time fMRI neurofeedback

Lijia Ma 1 , Min Guan 1 , Liang Li 2 , Li Tong 2 , Yong Zhang 3 , Dandan Zheng 3 , Bin Yan 2 , Meiyun Wang 1 , and Dapeng Shi 1

1 Radiology, People's Hospital of Zhengzhou University, ZhengZhou, HeNan, China, 2 National digital swiching system engineering and technological research center, HeNan, China, 3 GE Healthcare, Beijing, China

Previous studies found that by using real-time functional MRI (rtfMRI) neurofeedback, subjects could learn to control activation in the target brain region.We hypothesize that through rtfMRI neurofeedback,PHN patients could learn to control the activation in rACC,a region involved in pain perception and regulation.5 PHN patients performed a corresponding imagery task and were instructed to increase and decrease activation in rACC using rtfMRI neurofeedback.3/5 patients learned to change their fMRI signal with intermittent feedback training.Also there was a corresponding change in the perception of pain.This investigation may provide an alternative way for treatment of severe, chronic clinical pain in the future.

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