Abstract #3036
A BOLD-fMRI study of allodynic pain evoked by green laser stimuli of rats
Naoya Yuzuriha 1 , Sosuke Yoshinaga 1 , Makoto Hirakane 1 , Kazunari Kimura 1 , Shigeto Iwamoto 1 , Hiroshi Sato 2 , Akihiko Fujikawa 3 , Masayasu Takahashi 4 , and Hiroaki Terasawa 1
1
Faculty of Life Sciences, Kumamoto
University, Kumamoto, Japan,
2
Bruker
Biospin K.K., Yokohama, Kanagawa, Japan,
3
Bioimaging
Research Labs, Astellas Pharma Inc., Tsukuba, Ibaraki,
Japan,
4
Pharmacology
Research Labs, Astellas Pharma Inc., Tsukuba, Ibaraki,
Japan
The aim of this study is to establish an experimental
system applicable for the elucidation of the pathogenic
mechanism underlying allodynia. Using a BOLD-fMRI
method, the brain activation caused by allodynic pain
with green laser stimuli of fibromyalgia-model or normal
rats was evaluated. In the fibromyalgia-model rats,
positive BOLD responses were observed in the cingulate
cortex, the primary somatosensory cortex, the secondary
somatosensory cortex, the insula cortex, and the
thalamus. We successfully observed allodynia in the
animal model of fibromyalgia. The green laser greatly
facilitates the elucidation of the allodynia-specific
neural circuits.
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