Effects of Temporal Resolution on Granger Causality Analysis in Auditory-Motor fMRI
I-Jung Chen 1 , Yeh-Hsiung Cheng 2 , Tzu-Cheng Chao 1,2 , and Ming-Long Wu 1,2
Department of Computer Science and
Information Engineering, National Cheng Kung University,
of Medical Informatics, National Cheng Kung University,
In most fMRI studies, repetition time (TR) of 2-3
seconds is typically used to detect neuronal activities.
However, for fMRI studies targeting effective
connectivity (EC), such long TR might be unfavorable for
detecting causal relationship among brain regions. In
this study, effect of TR on detectability of EC using
conditional Granger causality analysis (CGCA) is
investigated. Results from auditory-motor fMRI
experiments show that short TR (<1 second) is preferred
for analyzing effective connectivity among brain
regions, which gives an important hint that current fMRI
protocols might need to be adjusted to better study
causal relationships in human brain.
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