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Abstract #3038

Effects of Temporal Resolution on Granger Causality Analysis in Auditory-Motor fMRI

I-Jung Chen 1 , Yeh-Hsiung Cheng 2 , Tzu-Cheng Chao 1,2 , and Ming-Long Wu 1,2

1 Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan, 2 Institute of Medical Informatics, National Cheng Kung University, Tainan, Taiwan

In most fMRI studies, repetition time (TR) of 2-3 seconds is typically used to detect neuronal activities. However, for fMRI studies targeting effective connectivity (EC), such long TR might be unfavorable for detecting causal relationship among brain regions. In this study, effect of TR on detectability of EC using conditional Granger causality analysis (CGCA) is investigated. Results from auditory-motor fMRI experiments show that short TR (<1 second) is preferred for analyzing effective connectivity among brain regions, which gives an important hint that current fMRI protocols might need to be adjusted to better study causal relationships in human brain.

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