Abstract #3051
Rethinking correlation in the brain: a resting-state fMRI study on the progression of cognitive decline
Mauro DiNuzzo 1,2 , Daniele Mascali 1,2 , Marta Moraschi 1,3 , Michela Fratini 1,3 , Tommaso Gili 3 , Girolamo Garreffa 1,3 , Bruno Maraviglia 1,3 , Laura Serra 3 , Marco Bozzali 3 , and Federico Giove 1,2
1
MARBILab, Enrico Fermi Center, Rome, Rome,
Italy,
2
Department
of Physics, U Sapienza, Rome, Rome, Italy,
3
Santa
Lucia Foundation IRCCS, Rome, Italy
We computed the maximum positive and minimum negative
values of the cross-correlation to obtain a
delay-independent measure of the correlation between
brain voxels and a seed region. Using standard
delay-sensitive analysis based on correlation
coefficient, we confirmed previous studies that
demonstrated decrease in spatial extension and amplitude
of the default-mode network (DMN) areas in Alzheimers
disease patients. However, this trend could not be
observed with cross-correlation analysis, indicating
that the loss of correlation of the DMN is possibly the
result of an increase in the delay of the propagation of
oscillations rather than a decrease in the strength of
mutual responses.
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