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Abstract #3051

Rethinking correlation in the brain: a resting-state fMRI study on the progression of cognitive decline

Mauro DiNuzzo 1,2 , Daniele Mascali 1,2 , Marta Moraschi 1,3 , Michela Fratini 1,3 , Tommaso Gili 3 , Girolamo Garreffa 1,3 , Bruno Maraviglia 1,3 , Laura Serra 3 , Marco Bozzali 3 , and Federico Giove 1,2

1 MARBILab, Enrico Fermi Center, Rome, Rome, Italy, 2 Department of Physics, U Sapienza, Rome, Rome, Italy, 3 Santa Lucia Foundation IRCCS, Rome, Italy

We computed the maximum positive and minimum negative values of the cross-correlation to obtain a delay-independent measure of the correlation between brain voxels and a seed region. Using standard delay-sensitive analysis based on correlation coefficient, we confirmed previous studies that demonstrated decrease in spatial extension and amplitude of the default-mode network (DMN) areas in Alzheimers disease patients. However, this trend could not be observed with cross-correlation analysis, indicating that the loss of correlation of the DMN is possibly the result of an increase in the delay of the propagation of oscillations rather than a decrease in the strength of mutual responses.

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