Caffeine alters the integration of relay and attention-associated areas in the functional connectivity of the visual cortex
Wen-Chau Wu 1,2
Graduate Institute of Oncology, National
Taiwan University, Taipei, Taiwan,
Imaging, National Taiwan University Hospital, Taipei,
Several recent studies showed that caffeine altered BOLD
signals and some examined the effect from a perspective
of signal processing and global contrast modulation.
Since caffeine has known pharmacological effects on
human behavior, we hypothesized that in addition to the
reported global effect, caffeine's influence on
resting-state BOLD signals might be spatially
differential and could be detected. In this study, the
hypothesis was tested in the visual cortex under the
eyes-open condition. Results showed that caffeine
slightly decreased the connection between visual cortex
and the lateral geniculate nucleus whereas the
integration of extrastriate visual areas was increased.
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