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Abstract #3065

Caffeine alters the integration of relay and attention-associated areas in the functional connectivity of the visual cortex

Wen-Chau Wu 1,2

1 Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, 2 Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

Several recent studies showed that caffeine altered BOLD signals and some examined the effect from a perspective of signal processing and global contrast modulation. Since caffeine has known pharmacological effects on human behavior, we hypothesized that in addition to the reported global effect, caffeine's influence on resting-state BOLD signals might be spatially differential and could be detected. In this study, the hypothesis was tested in the visual cortex under the eyes-open condition. Results showed that caffeine slightly decreased the connection between visual cortex and the lateral geniculate nucleus whereas the integration of extrastriate visual areas was increased.

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