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Abstract #3069

Estimating the Physiological Response Functions in Resting-State BOLD: The Effect of Acquisition Speed

Ali M Golestani 1,2 and J Jean Chen 1,2

1 Rotman Research Institute, Baycrest, Toronto, ON, Canada, 2 University of Toronto, Toronto, ON, Canada

Physiological signals have an effect on resting state BOLD, that typically described by transfer functions, estimated from datasets with typically repetition times of 2 s, preventing accurate sampling of all signal components. In this study we assess whether such limitations affect the estimation of the BOLD hemodynamic response function to physiological signals by using typical (TR = 2 s) and high temporal resolution (TR < 400 ms) data. We found that data acquired at typical temporal resolution produced transfer functions that are similar to those based on high temporal resolution data, suggesting the estimation to be insensitive to sampling rate.

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