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Abstract #3106

Acquisition of Basal and Evoked Potential CBF Response During Hyperbaric Exposure

Damon P Cardenas 1 , Eric Muir 1 , Shiliang huang 2 , and Timothy Duong 1

1 Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 2 MRI, Research Imaging Institute, San Antonio, Texas, United States

There are substantial interests in the effects of oxygen availability on neurovascular coupling and the response of cerebral blood flow (CBF) to neural activation. We evaluated forepaw-evoked CBF responses in rats under i) normobaric air, ii) normobaric oxygen, iii) hyperbaric air, and iv) hyperbaric oxygen (HBO). Basal CBF was not different under the four conditions, despite substantial increase of oxygen. Stimulus-evoked CBF was increased at moderately high [O2] compared to normobaric air, but returned to normal at very high [O2] under HBO, suggesting CBF responses are in some way regulated by oxygen-sensitive mechanisms.

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